On an income-adjusted basis, New Yorkers are the most miserable Americans while citizens of Lafayette, LA are the happiest. As MarketWatch reports, based on a Harvard study which 'adjusts' for age, sex, race, income and other factors, the following map indicates where the happiest Americans are (blue/green) and are not (red).
The happiest five cities are all in Louisiana, with Lafayette taking the crown (Louisiana is also the happiest state). The unhappiest cities, after New York City, are St. Joseph, Miss.; South Bend, Ind.; Erie, Penn.; and the Evansville, Ind.-Henderson, Ky. area.