On an income-adjusted basis, New Yorkers are the most miserable Americans while citizens of Lafayette, LA are the happiest. As MarketWatch reports, based on a Harvard study [3] which 'adjusts' for age, sex, race, income and other factors, the following map indicates where the happiest Americans are (blue/green) and are not (red).
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The happiest five cities are all in Louisiana, with Lafayette taking the crown (Louisiana is also the happiest state). The unhappiest cities, after New York City, are St. Joseph, Miss.; South Bend, Ind.; Erie, Penn.; and the Evansville, Ind.-Henderson, Ky. area.
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