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Using two separate drugs to lose weight can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight-loss and the people who go through it you should err to the side of caution and let the FDA do its job and demand some study be done so that the public understands the side effects and risks of the medications before we take them. Keep in mind that drug companies come in business to earn money and that they would say anything to keep people on the medications. Researchers found that participants using this drug for the year, lost weight within a month and have kept the load off through the 56 weeks from the study. Contrave can be a combination of the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs that are made up of several active ingredient, that might make them more efficient and safer. Combo-pilling may be the newest fad or also the newest ahead under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular is the fact that by right now there are no long term prescription diet pills that have been licensed by the FDA besides orlistat. #naltrexone . The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug could also raise hypertension and pulse rate, and must not be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must not used in patients with uncontrolled high blood pressure, and also by you are not heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients having a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients for the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking. Approving a drug using this many potentially lethal negative effects is inconsistent using the mission statement from the FDA. The power of the drug manufacturing lobby is blatantly evident within the approval of many drugs requiring 'post-marketing' studies which are clearly significant to overall drug safety within the US.