Do The Russians Have The Key To Solve America's Opioid Crisis?

A new medical breakthrough in southern Russia could hold the key in solving America’s opioid epidemic.

Scientists at Volgograd Sate Medical University are launching clinical trials into a pain-killing drug which outperforms morphine, and does not cause addiction. This would be a big step in the right direction, as the crisis in the United States spirals out-of-control.

In late October, President Trump addressed the nation outlining that the opioid crisis is now a ‘public health emergency’. Here are some mind-numbing facts indicating America has a major problem and if not fixed soon, it could produce major strains on the economy and healthcare system.

  • In 2016, more than two million Americans had an addiction to prescription or illicit opioids.
  • Since 2000, over 300,000 Americans have died from overdoses involving opioids.
  • Drug overdoses are now the leading cause of injury death in the United States, outnumbering both traffic crashes and gun-related deaths.
  • In 2015, there were 52,404 drug overdose deaths — 33,091 of those deaths, almost two-thirds, involved the use of opioids.
  • The situation has only gotten worse, with drug overdose deaths in 2016 expected to exceed 64,000.
  • This represents a rate of 175 deaths a day.

Department head of the Volgograd State Medical University, and RAS Member Alexander Spasov told TASS about this innovative medical breakthrough last Friday in Pyatigorsk, Russia.

“Together with our colleagues from the South Federal University, we created a drug which still has no specific name but is only referred to as RU-1205. Based on its effect, it outperforms such well-known painkillers as morphine and promedol and does not cause addictive side effects. Now, a full round of preclinical studies has been completed, and we are negotiating with two plants that are supposed to bankroll clinical research and initiate industrial production. At present, there isn’t a similar drug like this anywhere in the world,” Spasov announced at the 3rd International Research and Practice Conference on Experimental and Clinical Pharmacology.

TASS also interviewed clinical pharmacologist at Russia’s Ministry of Healthcare, RAS Member, Dean of Volgograd State Medical University Vladimir Petrov who highlighted RU-1205 “holds special significance for medicine”.

“A pain-killing drug, which outperforms morphine, and does not cause mental or physical addiction, is a huge breakthrough. This medication may set off a small revolution in pharmacology. It will save patients from subsequent addiction, it takes away the possibility of a drug habit setting in, which occurs when using morphine products over the long term,” Spasov said.

This could be a major blow to the Sackler family who has made billions selling OxyContin in the United States through Purdue Pharma since 1995. Some reports indicate the family has been a major contributor to the opioid crisis and there are no plans in stopping the flood of drugs onto city streets.

There are even reports Purdue is rapidly moving into Latin America, Asia, the Middle East, Africa and other regions, and pushing for broad use of painkillers that are highly addictive in places that are unprepared for the side-effects of addiction.

So far, RU-1205 is out of preclinical studies headed to the next phase of clinical research, then production. The idea that RU-1205 is a very real candidate in solving America’s opioid epidemic shows there is hope, but the drug could be a ways out before production indicating the crisis will deepen further.

If the miracle drug is ever cleared then goes into production, there is just one question we ask: Will the United States allow the Russians to fix the opioid crisis?


Escrava Isaura BarkingCat Wed, 11/22/2017 - 04:47 Permalink

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The Key To Solve America's Opioid Crisis? Just lie to them. They will never know. And, even if they do find out, which most won’t, those that found out will gravitate towards the lie, because it makes them feel better.  

In reply to by BarkingCat

philipat knukles Tue, 11/21/2017 - 22:09 Permalink

Big Pharma will wait for the Russians to file a Patent application which will divulge the molecular structure, then play pharmacology with it and, by inserting some side chains or F atom bridges into the structure, create a molecule sufficiently different to get its own patent. Countires like the US will then fast track the US variants for approval by the Big Pharma FDA Department whilst slow tracking the original russian invention and never approving it. Any further questions?

In reply to by knukles

besnook Tue, 11/21/2017 - 20:35 Permalink

so the russians created the opiod addiction crisis in the usa as part of a marketing plan to sell their own drug as a solution to the crisis. fn brilliant!

BeanusCountus besnook Tue, 11/21/2017 - 23:26 Permalink

Doubt that. But if it really works, Russian drug would be great for pain management folks. They would sell a ton of it on dr rx's. Hard to believe it doesn't give anyone a buzz tho. And if it does, and cures pain without addiction, they will corner the market. People will buy even more of it cuz America likes to escape.

Edit: off topic here, but why in the hell is zh continually "page had to reload(ing)" whenever U use it on mobile device? And, of course, reloads with a new ad served up. Anyone else having this problem? Really irritating. Solution appreciated. Thanks.

In reply to by besnook

Shockwave Iggby Tue, 11/21/2017 - 22:16 Permalink

Yep. Ive lived the Heroin nightmare, and luckily ive beat it so far. Physical addiction is very real, and doesnt give a fuck about anyones imaginary mental strengths. Opiates will make everyone that touches them addicted if used for for more than a few weeks. Physical addiction sets in sooner with every usage cycle. In the beginning i got no symptoms. Then it was after 2 weeks. Then a week. Then in a day. And it stays that way, once your body is adjusted, its adjusted. It doesnt go back.I also call bullshit on non-addictive pain meds. The brain isnt wired that way. Theyve had dozens of "miracle drugs" that all wind up being addictive. Because killing pain means shutting off the nerves. And its the reactivation of shut off nerves that causes the phyiscal addiction and withdrawals.

In reply to by Iggby

JuliaS Iggby Wed, 11/22/2017 - 00:03 Permalink

Depression, loneliness, history of physical abuse, brain trauma such as a mild concussion, or a genetic predisposition make people susceptible to addiction. Enough documented studied had been done on lab rats to illustrate every possible scenario. The bottom line is that addition is a manifestation of bigger underlying issues. Fight against drug dependency rarely addresses root causes, but that's the kind of society we live in.Food is also a drug. As we eat more and more crap, our chemical balance gets out of whack, once again, leading people to try band-aid medicines. Pills etc.Cell phones even. Addiction to the net is a dopamine hook. If you can't leave your phone at home - if that is how you deal with stress and boredom, then drugs will likely have an identical effect on you, as your brain is already trained for instant gratification. It knows how to bullshit itself.... and in the end, regardless of how healthy or mentally strong you are, drugs alter your state of consciousness. They re-wire the brain. As my friend puts it - it's an equivalent of taking a screwdriver and brushing it against a powered circuit board to see how pretty the sparks are. Something ought to fry in the process. The brain is an organ that sits in a protective casing. It's built like that for a reason - to keep the consciousness safe and shielded from outside influences, so that you don't immediately respond to every tiny stimulus and don't chase the warm spot of light like a cold-blooded reptile. The brain is protected from nearly everything except chemicals you ingest. If you eat, drink or inhale something bad, the brain is on its own and pretty much defenseless. Modern synthetic drugs will attack the brain with no mercy and they will turn the strongest resilient individual into a suggestion sponge.Addiction is real, but 9/10 times it's merely an effect of something else, and without addressing the particular cause, fighting the effect is nearly pointless.Cold turkey method works, but very very rarely. The focus should be on fixing one's life first by giving the brain rewards that are more fulfilling and long-lasting than the drugs themselves and doing it as early as possible. When suffering from addiction, time works against you. My neighbor is a nurse at a rehab clinic. We talk about these things all the time.

In reply to by Iggby

JuliaS Shockwave Wed, 11/22/2017 - 01:36 Permalink

My mother smoked all her life. I never developed the habit, even though I often watched her do it. At least she took care never to smoke inside the house, so I didn't have to smell the fumes if I didn't want to.When I got curious one day and wanted to try smoking, instead of telling me "no" or trying to lecture me about heath, she simply handed me a cigarette with: "go ahead and try it". I did, and guess what - I didn't like it. And that was that.Because we've always shared a strong bond and had trust in one another, I never had to go through the rebellious phase. While my classmates at school would pick up smoking and drinking to be cool like adults, or to get back at their parents, I never had the underlying urge. The strong family foundation did wonders for character-building, despite even the fact that my own mother was addicted to nicotine.To me personally that speaks volumes about the nature of addiction.As I remember one TED talk speaker saying: "When your gradma goes for a knee replacement, what they prescribe to her is stronger and more addictive than heroin. Yet somehow grandma doesn't automatically come back home as a junkie. Why is that?" he asks.I believe that family and social environment in general go a long way in determining whether someone will get hooked on substances or not. The problem with America and the modern world as a whole, is that we're destroying the family foundation, and preventing family formation in first place through economic meddling. We are turning kids into neglected orphans either by choice or through necessity. Therefore, it comes as no surprise as to why the opioid epidemic is happening. It's a symptom of a dying society. Not the cause, but merely an effect of backward priorities.

In reply to by Shockwave

Shockwave JuliaS Wed, 11/22/2017 - 09:28 Permalink

Yeah, I agree with all of that. My mother was the opposite, a fear monger and always said to me " you cant do that, itll ruin your life" about everything. No reason, no logic, no evidence, and the problem with that, is when you reach adulthood and realize the sky doesnt fall evertime someone tries something risky, then the child who never took those risks or tried to experience anything is going to start wondering just how much of what he was taught was bullshit. My mom also hid our families addiction issues with drugs and alcohol problems. My grandfather was a raging alcoholic after Vietnam, unlce struggled with opiate addiction after a car accident, and a distant cousin was bound to a wheelchair from shooting heroin into his spine. All of them beat their addiction by the time I was growing up.Instead of telling me about this and using it as an example, she lied and hid it, because she didnt want me to think "it was ok to use drugs". And when i wound up at my friends parties as a 20yr old, having never drank, never having experienced SHIT, and everyone was using cocaine and having a blast, not dying, not losing their jobs, not homeless and destitute, I had a moment where I decided, fuck it, im trying this too. It was a fatal mistake and within 6 months I had graduated to heroin usage.Had she been open and honest about our family history, and had let me make more choices for myself growing up, I dont think Id have made the decision to try that stuff that day. Thats exactly how a kid from a good family, with very strong ties and values, winds up a junkie.All the people I wound up running with once ai graduated from the party scene were mostly scum of the earth with no family and would never leave the addiction scene. Those people will always be that way, exactlt as you said, because of cultural decline and the death of the familt unit. And their kids were already growing up the same way.

In reply to by JuliaS

JuliaS Shockwave Wed, 11/22/2017 - 19:53 Permalink

I've been pressured at social events many times to pick up smoking and drinking and was able to resist. I clearly remember a conversation with a friend who accused me of "not knowing how to have fun". I responded with: "Nonsense! I am having fun!" But he wouldn't let go and kept on insisting saying things similar to what you're saying: "Just try it. The world isn't going to end. You'll see how good it is." In the end I got fed up and told him my theory - that he was conscious of his own addiction, probably trying to quit without success, and in order for him to feel better about himself, it was easier to corrupt other people that to fix his own life.And that was the end of our friendship. One so-called friend I don't regret losing.Peer pressure is where many addictions start. I've just spoken with a colleague over a lunch break about his smoking addiction. He said that he was trying to quit multiple times, but instead of getting support from his "fiends" they'd always pull him back in, because as soon as he started making progress, they'd all become conscious and jealous of it. When a person attempts to recover and fails - that makes all of the buddies feel good along the lines of: "You see! It's not just me who's like that. I don't have a weak character. Everyone's like that".The moral of the story is to choose one's friends carefully and not to be afraid to sever links if their behavior begins to influence you negatively. Important to have a clear mind about those things and to have a sense of identity - something that teenagers, especially nowdays, struggle with immensely. The world is changing quickly because of technology and people fall out of place, get depressed, begin looking for answers in unhealthy places. I have many friends who are on prescribed anti-depression meds. They are not themselves. What the drugs do to them appears worse than the depression they suffered from before. They say they are able to function because of drugs. I ask when the last time was they looked in the mirror.Perceived friends aren't always your real friends, and half the time, neither are the doctors. When it comes to staying out of trouble, you are your own best friend as far as I'm concerned.Sadly, we don't get to pick our parents and if they send us astray, then it's not really our fault... just our punishment.

In reply to by Shockwave

SaintInix Tue, 11/21/2017 - 20:39 Permalink

Yeah, we will never see it here.

Heroin profits are too good, especially after kicking all the addicts off the scripts.

There's a reason our military is protecting poppy fields in Afganistan. Lots of 'Off-books' revenue for the letter agencies to use to spy on us...

SaintInix Whoa Dammit Tue, 11/21/2017 - 21:07 Permalink

Yep, with all the other assorted 'Boggey-men', EBT cards, Bread and circuses, distraction and misdirection...

We'll be fighting each other or drooling on ourselves in a drug-induced stupor, or too fat and lazy from cheap, shitty food while we stuff our faces from the couch.

Each group has it's distraction, scape-goat, or terrifying evil to paralyze them.

It's only through the system of turning us against each other, or placating us, that they maintain control.

The day we all decide enough is enough, no one can stop us... That's a fact, we just need more people aware of it, and ready to do something about it.

In reply to by Whoa Dammit

SaintInix Dragon HAwk Tue, 11/21/2017 - 23:06 Permalink

Never said I'd organize it.

Doubt I'm charismatic enough to pull it off anyway.

I'm more of a logistical/strategy minded guy anyway. Seeing the big picture, and all the small things that make it come to fruition.

I'd be like the guy behind the guy, making sure things run smoothly. Being ready and prepared for anything, managing contingency plans, resupply, etc.

Trust me, I know what they would do. I will be one of the million, but I'm smart enough not to be the guy out in the front with a megaphone.

In reply to by Dragon HAwk

any_mouse Tue, 11/21/2017 - 20:42 Permalink

Two kinds of addiction, physical and psychological.

How many opioid users are trying to numb their anguish rather than their physical pain?

Numbing to reality is vaguely suicidal.

nailgunner44 Tue, 11/21/2017 - 22:02 Permalink

Kappa-opioid agonists are nothing new. There is a Connecticut-domiciled company called Cara Therapeutics with a very similar compound that is much further along in trials. Before that a Japanese company called Torii Pharma had a very similar compound approved for Uremic Pruitus. I'm afraid these guys are a bit late to the game.